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Takeda failed to properly inform consumers and prescribing doctors that use of actos for more than 12 months can put patients at an increased risk for developing bladder cancer takeda knew about the increased risk of bladder cancer , yet withheld this knowledge from the public rather than issue a recall on actos or properly warn patients and physicians, the company continued to market the drug as a safe and effective treatment had consumers been warned about the potentially life-threatening side effects of actos, they would have chosen another drug as treatment for their type 2 diabetes there was a feasible and safer alternative design that the manufacturer could have used to prevent harm suffered by plaintiffs without impairing the intended function of actos.

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Dos-latd wight gain occus whn ACTOS is usd alon in combination with oth antidiabtic mdications. Th mchanism wight gain is uncla but pobably involvs a combination luid tntion and at accumulation.

A summay th ovall incidnc and typs common advs vnts potd in tials ACTOS add-on tmtomin is povidd in Tabl 3. Tms that a potd psnt thos that occud at an incidnc >5% and mcommonly with th highst tstd dos ACTOS.

Th thaputic ct ACTOS in combination with sulonylua was obsvd in patints gadlss th sulonylua dos.

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I hypoglycmia occus in a patint co-administd ACTOS and an insulin sctagogu (.g., sulonylua), th dos th insulin sctagogu should b ducd.

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